Epidermolysis bullosa acquisita is an uncommon autoimmune blistering disorder characterized by tight subepithelial blisters at trauma sites. Epidermolysis bullosa acquisita, unlike Epidermolysis bullosa, is not hereditary and usually manifests in adulthood.
- Epidermolysis bullosa acquisita blisters are typically found in vulnerable locations like the hands, feet, elbows, knees, and buttocks. Mucosal involvement occasionally occurs, with blisters appearing in the mouth, nose, and eyes.
- EBA is more common in the forties and fifties of life. Males and females of all ethnicities are susceptible.
- Some EBA patients have been documented to have other autoimmune disorders, most often Crohn's disease and systemic lupus erythematosus, or health issues such as amyloidosis, multiple myeloma, and, in rare cases, lung cancer and lymphoma. Other patients merely have a skin condition.
- The main risk factor for acquiring epidermolysis bullosa is a family history of the illness. Epidermolysis bullosa is typically hereditary.
- The affected gene may be passed down from one of the disease's parents (autosomal dominant inheritance).
- It may also be inherited from both parents or originate as a novel mutation in the affected individual that can be passed on.
Hair abnormality,Upset stomach,Millium cyst,Millium cyst,Skin itching,Poor nail formation,Inflammatory bowel disease,Skin hyperpigmentation
Pruritus,Nail dystrophy,Inflammation of the large intestine,Hyperpigmentation of the skin,Abdominal pain,Milia,Abnormal hair morphology,Abnormal blistering of the skin
Azathioprine,Dapsone,Colchicine,Corticosteroids,Mycophenolate mofetil,GoldIntravenous immunoglobulin