Ichthyosis fetalis is autosomal recessive congenital disorder that affects the outer layers of the skin.
- This disorder is affected by problems in the ABCA12 named gene; the role of the ABCA12 gene is to protect the skin's outer layer from microorganisms by maintaining the skin's protective barrier. This gene works to transport the keratinocyte transmembrane lipid-protein.
- A dysfunction in this working system can lead to defective transportations of lipid to the stratum corneum; this leads to accumulations that are known as hyperkeratosis.
- This disease is transmitted by both parents having a defective gene.
- For both active gene parents the risk is twenty-five percent with each pregnancy that affects child.
- For the carrier child, there are fifty percent of chances to transmit this gene to their baby
- This disease is generally greater shown in the region where there is common consanguinity parental means both the parents are from the same blood origins.
Thick plate-like scales of skin,Eyelids and lips to turn inside out revealing the red inner linings,Breathing and eating difficulties,Small, swollen, and partially flexed hands and feet
A rare skin condition where the newborn infant is covered with plates of thick skin that crack and split apart
Oral retinoids (only used in severe cases),Antibiotic treatment,Skin softening emollients,Products containing alpha-hydroxy acids or urea