Localized Epidermolysis bullosa simplex (EBS) is a genetic disease, which means that it is caused by one or more genes not working correctly.
- The majority of EBS subtypes are inherited in a dominant manner. This means that an affected parent passes them on to half of his or her offspring. EBS affects both men and women equally.
- Epidermolysis bullosa simplex is often transmitted in an autosomal dominant manner, which means that only one copy of the mutated gene in each cell is required to induce the disorder.
- Some persons who are affected acquire the gene mutation from one infected parent. Other cases are caused by novel gene mutations and happen to people who have no family history of the condition.
- Epidermolysis bullosa simplex is inherited in a rare autosomal recessive type. The disease is inherited in an autosomal recessive manner, which means that two copies of the gene in each cell are changed.
- The ancestors of a person with an autosomal recessive condition typically have one copy of the mutated gene but do not have the disorder.
- Having a family history of epidermolysis bullosa is also a major risk factor for developing Epidermolysis bullosa.
Poor nail formation,Oral mucosal blisters,Millium cyst,Red-blue papule,Thin, atrophic scars,Plantar hyperkeratosis,Sweating, increased,Upper limb pain,Tingling,Subepidermal blistering with cleavage in the lamina lucida,Skin itching,Foot pain,Skin bullae
Oral mucosal blisters,Nail dystrophy,Mixed hypo- and hyperpigmentation of the skin,Erythematous papule,Plantar hyperkeratosis,Palmar hyperkeratosis,Hyperhidrosis,Paresthesia,Pruritus
Aluminum chloride (20%),Cyproheptadine,Tetracycline,Erythromycin, or botulimun toxin Localized Epidermolysis bullosa simplex(EBS) is a genetic disease, which means that it is caused by one or more genes not working correctly.