About morgagni-stewart-morel syndrome

What is morgagni-stewart-morel syndrome?

Hyperostosis Frontalis Interna is characterized by the thickening of the frontal bone of the skull. It is not clear that this disorder is actually rare. Some clinicians believe that it may be a common abnormality found in as many as 12 percent of the female population. The disorder may be found associated with a variety of conditions such as seizures, headaches, obesity, diabetes insipidus, excessive hair growth and sex gland disturbances. Increased serum alkaline phosphatase and elevated serum calcium may occur.

What are the symptoms for morgagni-stewart-morel syndrome?

Hypertrichosis(excessive hair growth) symptom was found in the morgagni-stewart-morel syndrome condition

Morgagni-Stewart-Morel (MSM) syndrome is a disorder characterized by thickening of the frontal bone of the skull (hyperostosis frontalis interna), as well as Obesity and excessive hair growth (hypertrichosis). Other signs and symptoms may include seizures, headaches, diabetes insipidus, and sex gland disturbances

What are the causes for morgagni-stewart-morel syndrome?

The cause of Morgagni-Stewart-Morel syndrome is not fully understood. Some instances of dominant inheritance have been reported, but whether it is autosomal dominant or X-linked dominant is not known.

What are the treatments for morgagni-stewart-morel syndrome?

Treatment may include medication for headaches and seizures and surgery to remove the excessive bone of the skull.

Is there a cure/medications for morgagni-stewart-morel syndrome?

Morgagni-Stewart-Morel syndrome is in-short, known as MSM syndrome.

  • The exact cause of the disease is yet to be unraveled, and its manifestations are yet to be completely described.
  • The disease was known to cause neurological manifestations.
  • However, endocrinal and metabolic abnormalities have been found to be associated with the disease.
  • The autosomal dominant genetic mutations have been believed to cause the disease.
  • The symptoms include excessive growth of the frontal bone of the skull, headaches, seizures, sex gland disturbances, and excessive growth of hair.

Treatment or management

  • MSM syndrome has no curative treatment, for the cause is not known.
  • The mortality rate due to the disease is low, which means the affected persons live a long life.
  • However, the clinical manifestations cost the patient's quality of life.Therefore, the symptoms can be managed.
  • Hyperostosis Frontalis Interna has no definite cure or therapy. Its effects are highly variable and may cause minor cognitive impairments in some patients. Surgical interventions such as decompression may be considered.
  • Obesity is another symptom. Dietary habits, for example, avoiding high carbohydrate and fat helps control obesity.
  • Anti-convulsants and anti-epileptic drugs reduce the frequency and severity of seizures.
  • Supportive treatment with painkillers with lower side effects is recommended for headaches.

Excessive growth of frontal bone of the skull (hyperostosis frontalis interna),Headaches,Seizures,Sex gland disturbances,Hypertrichosis(excessive hair growth)
Hyperostosis frontalis interna,Hypertrichosis
Anti-convulsants or anti-epileptic drugs,Painkillers

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