Morgagni-Stewart-Morel syndrome is in-short, known as MSM syndrome.
- The exact cause of the disease is yet to be unraveled, and its manifestations are yet to be completely described.
- The disease was known to cause neurological manifestations.
- However, endocrinal and metabolic abnormalities have been found to be associated with the disease.
- The autosomal dominant genetic mutations have been believed to cause the disease.
- The symptoms include excessive growth of the frontal bone of the skull, headaches, seizures, sex gland disturbances, and excessive growth of hair.
Treatment or management
- MSM syndrome has no curative treatment, for the cause is not known.
- The mortality rate due to the disease is low, which means the affected persons live a long life.
- However, the clinical manifestations cost the patient's quality of life.Therefore, the symptoms can be managed.
- Hyperostosis Frontalis Interna has no definite cure or therapy. Its effects are highly variable and may cause minor cognitive impairments in some patients. Surgical interventions such as decompression may be considered.
- Obesity is another symptom. Dietary habits, for example, avoiding high carbohydrate and fat helps control obesity.
- Anti-convulsants and anti-epileptic drugs reduce the frequency and severity of seizures.
- Supportive treatment with painkillers with lower side effects is recommended for headaches.
Excessive growth of frontal bone of the skull (hyperostosis frontalis interna),Headaches,Seizures,Sex gland disturbances,Hypertrichosis(excessive hair growth)
Hyperostosis frontalis interna,Hypertrichosis
Anti-convulsants or anti-epileptic drugs,Painkillers