Bullous pemphigoid is a rare skin condition that causes large, fluid-filled blisters. They develop on areas of skin that often flex - such as the lower abdomen, upper thighs or armpits. Bullous pemphigoid is most common in older adults.
- For moderate-to-severe cases of bullous pemphigoid, your healthcare provider may prescribe an oral corticosteroid, like prednisone in addition to a steroid-sparing immunomodulatory agent such as dapsone mycophenolate mofetil, azathioprine, methotrexate or chlorambucil.
- If you can't take corticosteroids or other immunomodulatory agents, your healthcare provider may prescribe oral tetracycline
- Treatment is focused on healing the skin and relieving itching while minimizing adverse side effects of medications.
Your doctor will likely prescribe one or a combination of the drugs:
- Corticosteroids. The most common treatment is prednisone, which comes in pill form. But long-term use can increase your risk of weak bones, diabetes, high blood pressure, high cholesterol and infection. Corticosteroid ointment can be rubbed on your affected skin and causes fewer side effects.
- Steroid-sparing drugs. These drugs affect the immune system by inhibiting the production of your body's disease-fighting white blood cells. Examples include azathioprine (Azasan, Imuran) and mycophenolate mofetil (CellCept). If your signs and symptoms involve the eyes or upper digestive tract, the drug rituximab (Rituxan) may be used if other approaches haven't helped.
- Other drugs that fight inflammation. An example is methotrexate (Trexall).
Itching skin,Large blisters that don't easily rupture when touched,Skin around the blisters that is normal, reddish or darker than normal,Eczema or a hive-like rash,Small blisters or sores in the mouth or other mucous membranes,In extreme cases- unexplained blistering, blisters on your eyes, signs of infection
A rare skin condition that causes large, fluid-filled blisters
Corticosteroid medications, such as prednisone,Steroid-sparing drugs,Other drugs that fight inflammation such as methotrexate (Trexall)