About weber-christian disease

What is weber-christian disease?

Weber-Christian disease facts

  • Weber-Christian disease is an uncommon inflammatory condition of the fatty tissues of the body.
  • It's a disease of unknown cause.
  • It most commonly affects the thighs and legs of women.
  • It's difficult to treat and may heal with permanent scars.

What is Weber-Christian disease? 

Weber-Christian disease is an uncommon inflammatory disease of the fatty tissues of the body. Weber-Christian disease is also referred to as idiopathic lobular panniculitis (ILP) and relapsing febrile nodular panniculitis syndrome.

The term Weber-Christian often refers to a group of diseases that involve the deep fat. These disorders first appear on the skin as reddish, tender, and raised (inflamed) areas. Mostly, Weber-Christian describes cases of recurring inflammation of special sections of fat called lobules. The exact cause of Weber-Christian panniculitis is unknown. The disorder is frequently associated with generalized symptoms such as fever and body aches.

Weber-Christian disease is most commonly seen in females 30-60 years of age. It can occur in both sexes, in all ages, and rarely in infants. There are no other known risk factors.

Usually, both sides of the body are affected, and the thighs and lower legs are the most frequent areas. The inflamed areas can lose their blood supply, the skin can actually die in the area, ooze yellowish drainage, and become infected. Scarring is common.

The appearance of the skin symptoms are usually accompanied by fever and overall malaise (feeling poorly). The skin lumps may vary in size but are usually small, the size of two to three fingertips or about 1-2 cm in size. The skin lumps may gradually flatten, soften, and start to decrease over several weeks. Frequently, the areas heal with a brownish or tan discoloration and leave a sunken scar from the underlying fat necrosis. Less commonly, the skin discoloration may take weeks to months to fade away completely and leave no scar.



What are the symptoms for weber-christian disease?

  • Weber-Christian disease can also cause symptoms other than in the skin, such as fever, fatigue, nausea, vomiting, weight loss, and joint pain. Occasionally, Inflammation occurs in other organs of the body to cause heart, lung, kidney, liver, and/or spleen problems.
  • Liver involvement may first cause abdominal pain. The skin symptoms provide perhaps the most important clue to the diagnosis of Weber-Christian syndrome.
  • Overall, symptoms with this syndrome may come and go, and relapses are common.



What are the causes for weber-christian disease?

The cause of Weber-Christian disease or idiopathic lobular panniculitis is not known. Idiopathic means unknown cause. A misdirected immune reaction may play a role. The cause may be related to an abnormal bodily response to the normal inflammation.



What are the treatments for weber-christian disease?

  • There is no cure or uniformly effective treatment that works for everyone with Weber-Christian disease. Possible treatments include oral medications that alter the immune-system reaction and decrease overall inflammation. Some patients have had improvement with medications including chloroquinethalidomidecyclophosphamidetetracyclinecyclosporineazathioprineprednisone, and a host of nonsteroidal medications like ibuprofen and indomethacin.
  • Accompanying treatments for the symptoms may include additional oral pain medications as well as topical salves to treat and prevent local skin infections.
  • Overall, when internal organs are inflamed, medicines directed toward the underlying inflammation are considered. In summary, treatment for Weber-Christian disease is nonspecific, and anti-inflammatory therapy may not be fully effective for everyone with the disease.



Is there a cure/medications for weber-christian disease?

An unusual inflammatory condition of the body's fatty tissues is called Weber-Christian disease.

  • Idiopathic lobular panniculitis (ILP) and recurrent febrile nodular panniculitis syndrome are other names for Weber-Christian disease.
  • A collection of disorders that affect the deep fat are frequently referred to as Weber-Christian diseases. Reddish, painful nodules are the earliest signs of these illnesses on the skin.
  • Weber-Christian mostly discusses instances of recurrent inflammation of distinct lobules of fat. The precise cause of Weber-Christian panniculitis is, however, unknown.
  • The weber-Christian disease has no known treatment that is universally successful or a cure. Oral medicines that modify immune system responses and reduce overall inflammation are potential therapies.
  • Chloroquine, thalidomide, cyclophosphamide, tetracycline, cyclosporine, azathioprine, prednisone, and a variety of nonsteroidal drugs like ibuprofen and indomethacin have all shown relief in certain patients.
  • Accompanying treatments for the symptoms may include additional oral pain medications and topical salves to treat and prevent local skin infections.
  • Medicines directed toward the underlying inflammation are considered when internal organs are inflamed. In summary, treatment for Weber-Christian disease is nonspecific, and anti-inflammatory therapy may not be fully effective for everyone with the disease.


Symptoms
Fever,Body ache,Recurring inflammation in the subcutaneous fat layer of the skin
Conditions
Reddish,Tender nodules on the skin
Drugs
Ibuprofen,Indomethacim



Video related to weber-christian disease