About deciduous skin

What is deciduous skin?

Peeling skin syndrome is a rare inherited skin disorder characterized by painless, continual, spontaneous skin peeling (exfoliation). Other findings may include blistering and/or reddening of the skin (erythema) and itching (pruritus). Peeling skin syndrome may clinically overlap with Netherton syndrome, which is also an autosomal recessive skin disorder belonging to the group of congenital ichthyoses, with onset in the neonatal period and infancy.

What are the symptoms for deciduous skin?

Acral Peeling skin syndrome causes painless peeling of the top layer of your skin called the epidermis. Peeling usually affects your hands and feet but may also affect your arms or legs. The word “acral” refers to a condition that affects your peripheral body parts.

Other symptoms can include easily plucked hairs and fragile skin. The skin under the Peeling skin may be Itchy and red, but the condition rarely causes Blisters or scarring.

Peeling generally starts from birth but can also appear in late childhood or early adulthood. In a 2016 case study, a child with acral Peeling skin syndrome developed blisters and peeling on his palms and soles at the age of 6 months.

Peeling tends to get worse after exposure to:

  • heat
  • humidity
  • moisture

Acral Peeling skin syndrome isn’t associated with any other health conditions and usually doesn’t significantly alter quality of life.

What are the causes for deciduous skin?

Acral peeling skin syndrome has been linked to mutations in the gene transglutaminase 5 (TGM5) and has less commonly been linked to mutations in the gene cystatin A (CSTA).

TGM5 is responsible for telling your body to create the TGM5 enzyme, which is found in many tissues, including your epidermis. The TGM5 enzyme helps create the cornified cell that acts as a protective barrier between your skin and the outside world.

If you don’t produce the TGM5 enzyme, the outermost layer of your skin can easily separate and peel off. Your hands and feet tend to be most affected because they’re the parts of your body most exposed to moisture and friction.

The gene CSTA codes for the CSTA enzyme, which plays a role in cell to cell adhesion.

Inheritance pattern

Gene mutations linked to the development of acral peeling skin syndrome are inherited in an autosomal recessive pattern. To develop symptoms, you need to receive one copy of the mutated gene from both of your parents.

If you only receive a gene mutation from one parent, you’ll be a carrier of the gene mutation but won’t develop symptoms. Your parents don’t need to have symptoms to be carriers.

If both parents have the gene mutation:

  • a child has a 25 percent chance of developing symptoms
  • a child has a 50 percent chance of carrying the gene mutation but not developing symptoms
  • a child has a 25 percent chance of neither carrying the gene mutation nor developing symptoms

What are the treatments for deciduous skin?

Treatment for acral peeling skin syndrome revolves around managing your symptoms.

Is there an acral peeling skin syndrome cure?

There’s no cure for this condition, although it rarely affects quality of life significantly or leads to complications.

Acral peeling skin syndrome home remedies

Symptoms are often manageable at home with a type of moisturizer called an emollient. Emollients soothe and soften dry or flaking skin by covering your skin with a thin, oily layer that helps seal in moisture. They come in a variety of forms, such as:

  • ointments
  • sprays
  • creams
  • lotions

Some of the most popular emollients include:

  • shea butter
  • cocoa butter
  • petroleum jelly
  • beeswax
  • mineral oil
  • coconut oil
  • jojoba oil
  • olive oil

You may also be able to minimize your symptoms by avoiding:

  • immersion in water
  • hot temperature
  • high humidity
  • friction on your hands or feet

Medical treatment

Medical treatments usually aren’t necessary. If you develop blisters, a doctor or other healthcare professional can lance them for you with a sterile needle to drain the fluid. They can also apply a light dressing to help you avoid an infection.

What are the risk factors for deciduous skin?

Is there a cure/medications for deciduous skin?

Deciduous skin is defined as the periodic, continuous, or seasonal peeling or shedding of the epidermal skin layer considering a generalized distribution.

  • Deciduous skin is also referred to as the peeling skin syndrome (PSS), which is a rare autosomal recessive form of ichthyosis.
  • This is clinically characterized by asymptomatic, superficial, and spontaneous peeling of the skin.
  • It is also histologically characterized by the peeling or shedding of the outer epidermal layer.
  • PSS is also presented with a generalized or acral distribution. Generalized destruction can be of type A which is non-inflammatory and type B, which is inflammatory. Some cases are difficult to classify.
  • It thus, suggests that there could be additional PSS subtypes.


  • There is no cure or effective treatment for deciduous skin. To decrease skin peeling, emollients are usually used.
  • Individuals affected with PSS must avoid immersion in water. They are advised to utilize aluminum antiperspirants or absorbing powders.
  • PSS is also treated by implementing skin softening ointments, specifically after a bath when the skin is soft and moist. This is likely to provide some relief to the patient.
  • Vaseline or plain petroleum jelly is also preferred.
  • Systemic retinoids such as vitamin A derivatives or corticosteroids are ineffective and may present adverse reactions or serious side effects.

Allergy,Eczema,Abnormal blistering of the skin,High hypermetropia,Ichthyosis,Erythema,Scaling skin,Skin erosion,Hyperpigmentation
Superficial, asymptomatic, spontaneous peeling of the skin,Histologically by a shedding of the outer layers of the epidermis
Emollients (oinments)

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