skin
- Animal-Type Melanoma/Pigmented Epithelioid Melanocytoma: History and Features of a Controversial Entity
Animal-type melanoma (ATM) was first described in the literature by Levene in 1979 in relation to a patient with a characteristic clinical presentation, and only later, rare and anecdotal case series ... Read More
- Evaluation of Melanocyte Loss in Mycosis Fungoides Using SOX10 Immunohistochemistry
Mycosis fungoides (MF) is a subtype of primary cutaneous T-cell lymphoma (CTCL) with an indolent course that rarely progresses. Histologically, the lesions display a superficial lymphocytic infiltrate... Read More
- Update on Superficial Spindle Cell Mesenchymal Tumors in Children
The diagnosis of cutaneous and subcutaneous spindle cell neoplasms in children is often challenging and has potential therapeutic and prognostic implications. Although correctly diagnosing dermatofibr... Read More
- Cutaneous Melanomas Arising during Childhood: An Overview of the Main Entities
Cutaneous melanomas are exceptional in children and represent a variety of clinical situations, each with a different prognosis. In congenital nevi, the risk of transformation is correlated with the s... Read More
- Panniculitis in Children
Panniculitides form a heterogenous group of inflammatory diseases that involve the subcutaneous adipose tissue. These disorders are rare in children and have many aetiologies. As in adults, the pannic... Read More
- Plaque-Like Dermatofibroma: Case Report of a Rare Entity
A case of a well-demarcated plaque measuring 11 cm without satellites of several years duration is presented. It showed typical histologic findings of dermatofibroma, prompting a diagnosis of plaque-... Read More
- Diagnostic Approach to Congenital Cystic Masses of the Neck from a Clinical and Pathological Perspective
Background: neck cysts are frequently encountered in pediatric medicine and can present a diagnostic dilemma for clinicians and pathologists. Several clinical items enable to subclassify neck cyst as ... Read More
- Aberrant Expression of Immunohistochemical Markers in Malignant Melanoma: A Review
Immunohistochemical stains are increasingly used to aid in the diagnosis of malignant melanoma, especially when the differentiation of the tumor is unclear based on examination with hematoxylin and eo... Read More
- Granular Cell Dermatofibroma: When Morphology Still Matters
Dermatofibroma, also known as fibrous histiocytoma, is one of the most common cutaneous soft-tissue tumors. Many variants of dermatofibromas have been described, and knowledge of these variations is... Read More
- Pseudomalignancies in Children: Histological Clues, and Pitfalls to Be Avoided
The term pseudomalignancy covers a large, heterogenous group of diseases characterized by a benign cellular proliferation, hyperplasia, or infiltrate that resembles a true malignancy clinically or h... Read More
- What to Look Out for in a Newborn with Multiple Papulonodular Skin Lesions at Birth
Multiple papulonodular skin lesions at birth can indicate the presence of various benign and malignant disorders. Although the lesions clinical aspect (color and consistency, in particular) may steer... Read More
- Artificial Intelligence in Dermatopathology: New Insights and Perspectives
In recent years, an increasing enthusiasm has been observed towards artificial intelligence and machine learning, involving different areas of medicine. Among these, although still in the embryonic st... Read More
- Immunohistopathological Analysis of Immunoglobulin E-Positive Epidermal Dendritic Cells with House Dust Mite Antigens in Naturally Occurring Skin Lesions of Adult and Elderly Patients with Atopic Dermatitis
The immunopathogenic role of house dust mite (HDM) allergens in the development of skin lesions in atopic dermatitis (AD) has not yet been precisely clarified. We immunohistopathologically evaluated t... Read More
- A New Case of Hybrid Epidermoid and Apocrine Cyst
We described a new case of a hybrid epidermoid and apocrine cyst, known to be a rare histopathological entity. The cyst was located in the axillary region and completely excised, without complication.... Read More
- Eccrine Nevus in the Forearm of a 16-Year-Old Presenting as Unilateral Hyperhidrosis: A Clinicopathological Correlation Paradigm
A case of a purely eccrine nevus in an adolescent patient presenting with focal hyperhidrosis on an area comprising the left forearm and the dorsal aspect of the left hand is described. No clinically ... Read More
- Erosive Pustular Dermatosis of the Scalp: A Clinicopathologic Study of Fifty Cases
Erosive pustular dermatosis of the scalp (EPDS) is an uncommon, pustular, idiopathic disorder typically occurring on the scalp of the elderly, whose diagnosis requires close clinicopathologic correlat... Read More
- Single-Center Clinico-Pathological Case Study of 19 Patients with Cutaneous Adverse Reactions Following COVID-19 Vaccines
(1) Background: Coronavirus disease 2019 (COVID-19) vaccines are currently employed on a population-wide scale in most countries worldwide. Data about unusual cutaneous adverse drug reactions (ADR) ar... Read More
- Venous Malformations in Childhood: Clinical, Histopathological and Genetics Update
Our knowledge in vascular anomalies has grown tremendously in the past decade with the identification of key molecular pathways and genetic mutations that drive the development of vascular tumors and ... Read More
- Dedifferentiated Melanoma: A Diagnostic Histological Pitfall Review of the Literature with Case Presentation
Dedifferentiated melanoma is a particular form of malignant melanoma with a progressive worsening of the patients clinical outcome. It is well known that melanoma can assume different histo-morpholog... Read More
- A Rare Case of Transient Acantholytic Dermatosis (AKA. Grovers Disease) with Concomitant Pediculosis Pubis: An Atypical Presentation and First Documented Case Report
A 66-year-old male presented with a one-month history of persistent pruritic eruptions distributed mainly on the trunk. A punch biopsy from the left upper abdomen revealed focal acantholytic dyskerato... Read More